Question Description
Only ONE page and one column, Arial font, size 12 and 1.0 space
Please return your assignment in WORD format
Dr. Lee’s lab focuses on finding the way to lower the COVID-19 death rate. Previous studies showed that COVID-19 viruses exploit host DNA damage mechanisms to promote viral replication by recruiting host DNA damage proteins to viral replication center. Furthermore, ATM/ATR DNA damage/repair pathways enhanced by this virus-mediated replication stress. Now, this is your research project, please try to find the solution for below questions,
- First, we are trying to figure out which type of DNA damage (double-stranded breaks, DSBs or single-stranded breaks, SSBs) may observe in COVID-19 virus-infected host cells (2 points)? Why (6 points)?
- If it is DSBs damage accumulated in COVID-19 virus-infected host cells, could you name Two DSBs repair mechanism from our textbook or lectures (2 points)?
- Please describe detail steps of BOTH DSBs repair mechanisms at the molecular level, for examples which proteins involved, what is the role of each protein and more (10 points)?
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